Statins associated with lower total testosterone Statin therapy is associated with lower total but not bioavailable or free testosterone in men with type 2 diabetes. Running title: Statins associated with lower total testosterone
نویسندگان
چکیده
Department of Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, United Kingdom Academic Unit of Diabetes, Endocrinology and Metabolism, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, United Kingdom Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
منابع مشابه
Statin Therapy Is Associated With Lower Total but Not Bioavailable or Free Testosterone in Men With Type 2 Diabetes
OBJECTIVE There is a high prevalence of hypogonadism in men with type 2 diabetes. This will lead to an increase in assessments of hypogonadism. Statins could potentially decrease testosterone levels by reducing the availability of cholesterol for androgen synthesis. We compared testosterone levels and hypogonadal symptoms with statin use in a cross-sectional study of 355 men with type 2 diabete...
متن کاملThe Evaluation of Serum Level of Testosterone and Sex Hormone- Binding Globulin in Men with Type 2 Diabetes
OBJECTIVE: To evaluate the relationship between serum level of testosterone and sex hormone-binding globulin in men with type 2 diabetes. MATERIALS AND METHODS: In this case-control study, forty men aged 40-70 with type 2 diabetes mellitus were randomly selected and compared with 40 non-diabetic men. The two groups were matched for their age and BMI. After complete observation and examination...
متن کاملTreatment with statins and testosterone levels in men.
INTRODUCTION Statins belong to the most commonly used medicines worldwide. They affect cholesterol synthesis and thus they may suppress steroidogenesis. Our aim was to evaluate whether the use of statins is associated with the concentration of sex hormones.Material and methods/Results: In a population sample of men (n = 237) we found that subjects receiving statins had significantly lower conce...
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OBJECTIVE Some evidence suggests an inverse association between type 2 diabetes and androgens in men and a positive association between type 2 diabetes and androgens in women. The purpose of this community-based study was to evaluate sex differences in the association between endogenous total and bioavailable estrogen and testosterone levels and glucose tolerance status. RESEARCH DESIGN AND M...
متن کاملClinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity.
OBJECTIVE The aim of our study was to assess the prevalence of clinical hypogonadism, based on both symptoms and biochemical available measures of testosterone deficiency, in men with type 2 diabetes. RESEARCH DESIGN AND METHODS In a cross-sectional study of 355 type 2 diabetic men aged >30 years, total and bioavailable testosterone, sex hormone-binding globulin, BMI, and waist circumference ...
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